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Fig. 3 | Biomarker Research

Fig. 3

From: Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development

Fig. 3

CircRNA host genes are downregulated in tumor tissues. A Volcano plots of the differential expression analysis of the differentially expressed circRNA host genes levels in lesions with respect to adjacent mucosa. Red dashed line indicates adj. p < 0.05. Black border identifies significant results. B Scatter plots of the relationships between log2FCs computed for the differentially expressed circRNAs and their host genes. The label highlights the most significant up/downregulated circRNA host genes. C Dot plot of the differential expression of circRNA host gene levels between lesions and adjacent mucosa samples in patients stratified according to disease stage. The dot size is proportional to the analysis significance. On the right, bar plot of the results of the Spearman correlation analysis between circRNA and their host gene levels. *p < 0.05; ***p < 0.001. D Heatmap reporting the differences in circRNA host gene levels (log2FC) between lesions and adjacent mucosa considering samples from ten public independent datasets

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Biomarker Research

ISSN: 2050-7771

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